RC1339/APRC FROM RICKETTSIA CONORII IS A NOVEL ASPARTIC PROTEASE WITH PROPERTIES OF RETROPEPSIN-LIKE ENZYMES.

RC1339/APRc from Rickettsia conorii is a novel aspartic protease with properties of retropepsin-like enzymes.

Members of the species Rickettsia are obligate intracellular, gram-negative, arthropod-borne pathogens of humans and other mammals.The life-threatening character of diseases caused by many Rickettsia species and the lack of reliable protective vaccine against rickettsioses strengthens the importance of identifying new protein factors for the potent

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Enhanced Persistent Luminescence from Cr3+-Doped ZnGa2O4 Nanoparticles upon Immersion in Simulated Physiological Media

Near-infrared persistent luminescence (PersL) nanoparticles (NPs) have great potential in biomedical applications due to their ability to continuously emit tissue-penetrating light.Despite numerous reports on the distribution, biological safety and other consequences of PersL NPs in vitro and in vivo, there has been a lack of studies on the optical

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Combination of Crizotinib and Osimertinib in T790M+ EGFR-Mutant Non-Small Cell Lung Cancer with Emerging MET Amplification Post-Osimertinib Progression in a 10-Year Survivor: A Case Report

Tyrosine kinase inhibitors (TKIs) represent the standard treatment for Gift Set patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations.The duration of the response is, however, limited in time owing to the development of resistance mechanisms to both first- and second-generation agents such as S

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Enhancing Financial Resilliance: a Study of Financial Ratios to Predict Financial Distress in Indonesian Life Insurance Firms During Covid-19 Era

The Covid-19 phenomenon and a series of insurance default events increase the risk of bankruptcy.Financial distress analysis becomes a crucial study Acrylic Plaque to prevent bankruptcy.This research was conducted to present empirical evidence of the influence of premium growth ratio, liquidity ratio, risk-based capital, investment adequacy ratio,

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Sustainable Writing Support: A Campus-wide Module to Support Bachelor Thesis Writing at a University of Technology

Higher education is today characterised by increasing student Edibles groups and high pressure on teaching staff.In these circumstances, it may be difficult to provide appropriate scaffolding of activities that many students find challenging, for example, academic and discipline-specific writing.It may also be difficult to align such support with p

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